Tau, β-Amyloid, and Glucose Metabolism Following Service-Related Traumatic Brain Injury in Vietnam War Veterans: The Australian Imaging Biomarkers and Lifestyle Study of Aging-Veterans Study (AIBL-VETS)

TL Cummins; V Doré; A Feizpour; N Krishnadas; P Bourgeat; A Elias; F Lamb; R Williams; M Hopwood; S Landau; VL Villemagne; M Weiner; CC Rowe

Journal article

Tau, β-Amyloid, and Glucose Metabolism Following Service-Related Traumatic Brain Injury in Vietnam War Veterans: The Australian Imaging Biomarkers and Lifestyle Study of Aging-Veterans Study (AIBL-VETS)

TL Cummins, V Doré, A Feizpour, N Krishnadas, P Bourgeat, A Elias, F Lamb, R Williams, M Hopwood, S Landau, VL Villemagne, M Weiner, CC Rowe

Journal of Neurotrauma | Published : 2023

DOI: 10.1089/neu.2022.0172

Abstract

Traumatic brain injury (TBI) is common among military veterans and has been associated with an increased risk of dementia. It is unclear if this is due to increased risk for Alzheimer's disease (AD) or other mechanisms. This case control study sought evidence for AD, as defined by the 2018 National Institute on Aging - Alzheimer's Association (NIA-AA) research framework, by measuring tau, β-amyloid, and glucose metabolism using positron emission tomography (PET) in veterans with service-related TBI. Seventy male Vietnam war veterans - 40 with TBI (age 68.0 ± 2.5 years) and 30 controls (age 70.1 ± 5.3 years) - with no prior diagnosis of dementia or mild cognitive impairment underwent β-amyloi..

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University of Melbourne Researchers

Malcolm Hopwood Author

Victor Villemagne Author

Christopher Rowe Author

Related Projects (2)

TAU AND BETA-AMYLOID DEPOSITION, MICROHEMORRHAGE AND BRAIN FUNCTION AFTER TRAUMATIC BRAIN INJURY IN WAR VETERANS

PUBLIC ABSTRACT Abstract not available

THE PREVALENCE OF ALZHEIMER'S DISEASE PATHOLOGY AFTER TRAUMATIC BRAIN INJURY IN VETERANS AND CIVILIANS: A BIOMARKER STUDY OF BETA-AMYLOID AND TAU

PUBLIC ABSTRACT Background: Some old research studies have suggested that people with brain injuries maybe 400% more likely to lose their ..

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

The study was supported by grants from the National Health and Medical Research Council (NHMRC) (award numbers APP1127007, APP10475151), the U.S. Department of Defense U.S. Army Medical Research and Materiel Command (award number W81XWH-14-1-0418) and Piramal Imaging who marketed Florbetaben at the time of the study. The funding sources had no input into the design of this study, the analysis of data, or writing of the manuscript.